Gender differences in neurotoxicity
Gender differences in alcohol’s effects on the brain for adolescents in alcohol recovery adolescent alcohol use and alcohol use disorders among adolescent constitute serious problems by grade 12, nearly 60 percent of adolescents have been drunk, and studies suggest that approximately 6 percent of adolescents have an alcohol use disorder. This project involves understanding the role of paraoxonases 1 and 2 (pon1 and pon2) in modulating oxidative stress-induced neurotoxicity both pons exert antioxidant effects, but have different tissue localizations, with pon1 situated in liver and blood, and pon2 intercellularly in all tissues including the brain. Sex-specific and gender-specific research: examples frances northington, md professor department of pediatrics glutamate neurotoxicity testosterone withdrawal protects against mcao ischemia gender differences exist in incidence and outcome of.
The differences in glial activation between methamphetamine and mdma observed in the present study could have implications for the prognosis of the injury induced by these drugs to investigate short-term and long-term effects of ecstasy use on mood and its association with 5-ht neurotoxicity, dose, and gender in humans methods: fifteen. Rat strain- and gender-related differences in neurobehavioral screening: acute trimethyltin neurotoxicity virginia c moser neurotoxicology division, us environmental protection agency. The effect of gender and the neurotrophin, bdnf, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice the effect of gender and the neurotrophin, bdnf, upon methamphetamine-induced neurotoxicity of.
The identification of these sex-dependent differences in markers provides a foundation for more exhaustive evaluation of their impact upon, and treatment of, disorders/neurotoxicity of the nigrostriatal dopaminergic system and the bases for the differences that exist between females and males. Research innovation publications anesthetic neurotoxicity in congenital we explore reconstructive surgical timelines for common congenital hand differences in light of the available anesthetic neurotoxicity evidence, with an emphasis on preoperative counseling color, religion (creed), sex, gender identity or expression, sexual. In fact, the way testosterone acts in the body points to some interesting gender differences some interesting differences between men and women: men produce 20 to 30 times more testosterone than women men need to replenish their testosterone levels to feel successful. This likely promotes nmdar overactivity and contributes to neurotoxicity during ewd, however, little is known regarding such effects in early neonatal brain the present study compared the effects of ewd and polyamine exposure on toxicity in hippocampal slice cultures derived from postnatal day 2 (pnd 2) or postnatal day 8 (pnd 8) day-old rats. Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice.
Sex differences in neuroadaptation to alcohol and withdrawal neurotoxicity authors to dependence and alcohol-related neurodegeneration furthermore, the role that hormonal status has in influencing neuroadaptation to alcohol and withdrawal mulholland pj, littleton jm, prendergast ma (2008) age and gender differences in response to. Title = manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity, abstract = this symposium comprised five oral presentations dealing with recent findings on mn-related cognitive and motor changes from epidemiological studies across the life span. Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system dean e dluzen, katherine r mickley department of anatomy, northeastern ohio universities college of medicine, (neoucom), 4209 state route 44, po box 95. Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of quebec (canada) environ res 107/3: 380–392.
Gender differences in neurotoxicity
Estrogen, anti-estrogen, and gender differences in methamphetamine neurotoxicity and testosterone (t) on methamphetamine (meth)-induced neurotoxicity in female and male cd-1 mice treatment of gonadectomized females with a physiological regimen of e significantly diminished the amount of striatal dopamine (da) depletion to meth compared. Neurotoxicology, signal-transduction systems in developmental neurotoxicity, molecular mechanisms of neurotoxicity, biochemical markers of neurotoxicity, children’s health, food additives and contaminants, genetic susceptibility, in vitro toxicology, pesticides and children, alcohol, cell-cell interactions in developmental neurotoxicity. These findings reveal learning deficits at low levels of th insufficiency, potential gender differences in susceptibility, and the power of postnatal serum t4 levels to predict alterations in some but not all toxicological and functional endpoints. Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking there is a need rat strain- and gender-related differences in neurobehavioral screening: acute trimethyltin neurotoxicity j toxicol environ.
- Recent human and animal studies suggest that gender dimorphic profiles are emerging in terms of neurotoxicity, moreover that gender differences in neurotoxicity are more widespread than one may expect.
- Gender-related differences in susceptibility to chemical exposure to neurotoxicants have not received sufficient attention although a significant number of epidemiological studies on the neurodevelopmental effects of metal exposure has been published in the last twenty years, not many of them have considered the possible gender-specific effects of such exposure.
- In addition to identifying the basal gender differences of these transporters, another goal of the present study was to examine the gender differences of these genes in lateral cp and brain (with the lateral cp removed) in the response to an hepatotoxic dose of acetaminophen (apap) in wild-type (wt) and nrf2-/- mice.
Gender differences are also reported in thyroid path-ologies for example, in the italian population thyroid ectopia is significantly higher in girls than in boys and moreover, girls with congenital hypothyroidism require lower doses of initial therapy in order to achieve. T1 - gender differences in the effect of tobacco use on brain phosphocreatine levels in methamphetamine-dependent subjects au - sung,young hoon au - yurgelun-todd,deborah a. There is increasing evidence of gender-specific differences in stroke symptoms, diagnosis, peri-procedural risk, treatment, and preventive interventions 5–12 for example, results from the women’s health study 11 and the physician’s health study 12 revealed that aspirin is an efficacious measure for primary stroke prevention in women but.